
Vardenafil hydrochloride trihydrate
CAS No. 330808-88-3
Vardenafil hydrochloride trihydrate ( BAY 38-9456 | Vardenafil HCl | Levitra | Staxyn | Vivanza )
产品货号. M18429 CAS No. 330808-88-3
伐地那非盐酸盐三水合物是一种新型 PDE 抑制剂,对 PDE5 和 PDE1 的 IC50 分别为 0.7 和 180 nM。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥316 | 有现货 |
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10MG | ¥518 | 有现货 |
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25MG | ¥1029 | 有现货 |
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50MG | ¥1596 | 有现货 |
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100MG | ¥2535 | 有现货 |
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200MG | ¥3791 | 有现货 |
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500MG | ¥6099 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Vardenafil hydrochloride trihydrate
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述伐地那非盐酸盐三水合物是一种新型 PDE 抑制剂,对 PDE5 和 PDE1 的 IC50 分别为 0.7 和 180 nM。
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产品描述Vardenafil, also known as BAY 38-9456, is a PDE5 inhibitor used for treating erectile dysfunction. Vardenafil (VAR) is synthetic, highly selective, and potent inhibitor of phosphodiesterase-5 which competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. It is clinically approved for treatment of erectile dysfunction in men, including diabetic and postprostatectomy patients.(In Vitro):Vardenafil hydrochloride trihydrate specifically inhibits the hydrolysis of cGMP by PDE5 with an IC50 of 0.7 nM.Vardenafil hydrochloride trihydrate increases intracellular cGMP levels in the cavernosum tissue of the penis, thus results increasing the dilation of the body's sinuses and blood flow.(In Vivo):Vardenafil hydrochloride trihydrate (I.V.; 0.03 mg/kg) exhibits facilitator effects in rats with cavernous nerve injury.Vardenafil hydrochloride trihydrate (I.V.; 0.17 mg/kg once daily; 7 days) protects liver against Con A–induced hepatitis, and decreases the expression of NF-??B and iNOS in hepatic tissue.Vardenafil hydrochloride trihydrate (P.O.; 10 mg/kg once daily; 25 weeks) prevents the reduction of tissue cGMP levels and the increase in 3-NT generation in ZDF hearts.
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体外实验Vardenafil hydrochloride trihydrate specifically inhibits the hydrolysis of cGMP by PDE5 with an IC50 of 0.7 nM.Vardenafil hydrochloride trihydrate increases intracellular cGMP levels in the cavernosum tissue of the penis, thus results increasing the dilation of the body's sinuses and blood flow.
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体内实验Vardenafil hydrochloride trihydrate (I.V.; 0.03 mg/kg) exhibits facilitator effects in rats with cavernous nerve injury.Vardenafil hydrochloride trihydrate (I.V.; 0.17 mg/kg once daily; 7 days) protects liver against Con A–induced hepatitis, and decreases the expression of NF-??B and iNOS in hepatic tissue.Vardenafil hydrochloride trihydrate (P.O.; 10 mg/kg once daily; 25 weeks) prevents the reduction of tissue cGMP levels and the increase in 3-NT generation in ZDF hearts. Animal Model:Male rat (9-week-old) underwent surgery for laparotomy or bilateral cavernous nerve (CN) crush injury Dosage:0.03 mg/kg Administration:Intravenous injection Result:Restored normal erectile responses with a combind administration of BAY 60-4552 (0.03, 0.3 mg/kg).Animal Model:Liver injury induced by Con A in male Swiss albino mice (20 ± 2 g)Dosage:0.17 mg/kg Administration:Intravenous injection; once daily, for 7 days; as a pretreatment Result:Reduced the levels of serum transaminases and alleviated Con A-induced hepatitis.Animal Model:Male 7-week-old Zucker diabetic fatty (ZDF) rats (preserved ejection fraction, HFpEF)Dosage:10 mg/kg Administration:Oral gavage; once daily, for 25 weeks Result:Improved myofilament function in diabetic rat hearts.
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同义词BAY 38-9456 | Vardenafil HCl | Levitra | Staxyn | Vivanza
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通路Others
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靶点Other Targets
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受体PDE1| PDE5
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研究领域Cardiovascular Disease
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适应症——
化学信息
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CAS Number330808-88-3
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分子量579.11
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分子式C23H32N6O4S·HCl·3H2O
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纯度>98% (HPLC)
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溶解度——
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SMILESn12[nH]c(nc(=O)c1c(nc2CCC)C)c1c(ccc(c1)S(=O)(=O)N1CCN(CC1)CC)OCC.Cl.O.O.O
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化学全称2-(2-ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one dihydrochloride trihydrate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1 Saenz de Tejada I, et al. Int J Impot Res, 2001, 13(5), 282-290.
产品手册




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